I have been trying to get it to work since I posted this and still nothing - at this point i have also moved the Vortex download folder to the same drive (C drive to D drive) and still nothing. (Also, there are no cycles or issues within Vortex that the program has mentioned, and if it had I have already messed with the load order.) No clue at this point what else I could possibly do so I am giving in and asking for help after a long night of trial and error. I have downloaded BethINI from nexus to help and still nothing.
All drivers are up to date, cache is verified, I attempted to disable every mod I have and then launch the game just in case any of them gave me items on startup that could have caused the problem, but nothing.
I am currently running just over 200 mods on Vortex and have tried running the game in many different ways, same res as monitor, windowed, administrator, etc. So this is about my 5th playthrough of FO4 and I usually have similar issues but this time I just can't figure out how to fix it.
